Oxygen → Benzenepropanoic acid, α-methyl-4-(trifluoromethyl)-, ethyl ester

反応式

[CH3:1]/[C:2](=[CH:8]\[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)/[C:3]([O:5][CH2:6][CH3:7])=[O:4].O=O>[Pd].CO>[CH3:1][CH:2]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:16])([F:18])[F:17])=[CH:13][CH:14]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

実験手順

Dissolve ethyl(E)-2-methyl-3-[4-(trifluoromethyl)phenyl]prop-2-enoate (2.58 g, 10 mmol) in a suspension of 10 wt % Pd—C (258 mg)/MeOH (20 mL) in an RBF under nitrogen, as exposure of Pd—C to oxygen can lead to fire. Carefully purge the flask with hydrogen and stir the resulting mixture under hydrogen (1 Atm) for 16 h. Purge the flask nitrogen and degas the solvent to remove all hydrogen before exposing to air. Filter the suspension through a pad of celite. Concentrate the filtrate to give the title compound (2.39 g).