Hydrochloric Acid → alpha,alpha-Dimethyl-4-(trifluoromethyl)benzenepropanoic acid
反応式
[CH3:1][C:2]([CH3:19])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].Cl>CO>[CH3:1][C:2]([CH3:19])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]参加物
5
反応条件
- 温度
- 80 °C
実験手順
Dissolve ethyl 2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoate (400 mg, 1.46 mmol) in MeOH (2 mL) and add aqueous NaOH solution (3 mL of 3 N). Heat to 80° C. and stir for 3 h. Cool to ambient temperature and acidify with 1 N HCl until pH 4. Extract with EtOAc. Combine organic extracts, wash with brine, dry over sodium sulfate, filter, and concentrate to give the title compound (272 mg).
後処理
- temperatureCool to ambient temperature
- extractionExtract with EtOAc
- washCombine organic extracts, wash with brine
- dry with materialdry over sodium sulfate
- filtrationfilter
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-018241eabb054d13ba718f99114f0494
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206139B2
反応ノート
読み込み中…