Triphenylphosphine → HCID 86718007、化合物

HRID 1500469ノート

反応式

HRID 1500469 の反応式
O[C@@H:2]([CH3:12])[CH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[OH:11].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:12][C@@H:2]1[CH2:3][C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[O:11]1

参加物

5

反応物 3

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 86718006HCID 86718006、化合物

生成物 1

HCID 86718007HCID 86718007、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of (S)-2-(2-hydroxypropyl)-4-methylphenol (3c) (1.6 g, 8.4 mmol) and triphenylphosphine (2.7 g, 10 mmol) in THF (60 mL) was added DIAD at ambient temperature. It was concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1) to give the title compound (3d).

後処理

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1)

出典と根拠

ORDレコード
ord-2e574ee400bf45f883d79ad70b89b075
出典データセット
uspto-grants-2015_12
特許番号
US09206166B2

反応ノート

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