4-(Benzylamino)-1-methylcyclohexanol → Trans-4-amino-1-methyl-cyclohexanol

HRID 1500887

反応式

HRID 1500887 の反応式
C([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1

参加物

4

反応物 1

HCID 674652054-(Benzylamino)-1-methylcyclohexanol

生成物 1

HCID 18331273Trans-4-amino-1-methyl-cyclohexanol収率 100.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 4-(benzylamino)-1-methylcyclohexanol (4.9 g, 22.3 mmol) in MeOH (150 mL) was stirred with 7% Pd/C (700 mg) under H2 atmosphere at RT overnight. The resulting mixture was filtered to remove Pd/C and the filtrate was concentrated in vacuo to afford a white solid (2.9 g, quantitative yield) which was used in the next step directly.

後処理

  1. filtrationThe resulting mixture was filtered
  2. customto remove Pd/C
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-a0f492c4bb0c4f54a302e748239e6f5a
出典データセット
uspto-grants-2015_12
特許番号
US09206191B2

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