Borane;tetrahydrofuran → HCID 89923979、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH:11][C:12](=O)[CH2:13][C:14]([F:17])([F:16])[F:15])=[C:4]([F:19])[CH:3]=1.B.O1CCCC1>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH:11][CH2:12][CH2:13][C:14]([F:15])([F:16])[F:17])=[C:4]([F:19])[CH:3]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of N-(4-chloro-2-fluoro-6-nitrophenyl)-3,3,3-trifluoropropanamide (350 mg, 1.1 mmol) in 15 mL of THF was added borane-tetrahydrofuran solution (25 mL, 1 M). The mixture was heated to 70° C. and stirred overnight. The reaction was quenched with MeOH and the solvents were removed by evaporation to give 4-chloro-6-fluoro-N-(3,3,3-trifluoropropyl)benzene-1,2-diamine (300 mg, yield: 82%) as crude oil. MS obsd. (ESI+) [(M+H)+] 257.
後処理
- customThe reaction was quenched with MeOH
- customthe solvents were removed by evaporation
出典と根拠
- ORDレコード
- ord-b83c6805c78d4dbea8eb488945aa635a
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206191B2
反応ノート
読み込み中…