Thionyl Chloride → 5-chloro-2-(chloromethyl)-7-fluoro-1-(2-(methylsulfonyl)ethyl)-1H-indole

HRID 1500939ノート

反応式

HRID 1500939 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[N:7]([CH2:12][CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])[C:6]([CH2:18]O)=[CH:5]2.O=S(Cl)[Cl:22]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[N:7]([CH2:12][CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])[C:6]([CH2:18][Cl:22])=[CH:5]2

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 89924003HCID 89924003、化合物

生成物 1

HCID 899239435-chloro-2-(chloromethyl)-7-fluoro-1-(2-(methylsulfonyl)ethyl)-1H-indole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of {5-chloro-7-fluoro-1-[2-(methylsulfonyl)ethyl]-1H-indol-2-yl}methanol (130 mg, 0.43 mmol) in 40 mL of DCM was stirred with SOCl2 (254 mg, 2.13 mmol) at RT and the reaction was monitored by LC/MS. After all starting materials were consumed, the mixture was concentrated in vacuo to afford the crude 5-chloro-2-(chloromethyl)-7-fluoro-1-[2-(methylsulfonyl)ethyl]-1H-indole, which was used for next step directly.

後処理

  1. customAfter all starting materials were consumed
  2. concentrationthe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-3c5d63f0ad0c411f89469dc00bef3bed
出典データセット
uspto-grants-2015_12
特許番号
US09206191B2

反応ノート

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