Trifluoroacetic acid → 4-(tetrahydrofuran-2-yl)benzoic acid
反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]1[CH:18]=[CH:17][C:9]([C:10]([O:12]C(C)(C)C)=[O:11])=[CH:8][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]1[CH:18]=[CH:17][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1参加物
4
実験手順
To a solution of tert-butyl 4-(tetrahydrofuran-2-yl)benzoate (350 mg, 1.41 mmol) in dichloromethane (10 mL) was added 2,2,2-trifluoroacetic acid (2 mL). The resulting mixture was stirred at room temperature for 0.5 hours. The mixture was concentrated to give 4-(tetrahydrofuran-2-yl)benzoic acid (200 mg, 74%) as a white solid.
後処理
- concentrationThe mixture was concentrated
出典と根拠
- ORDレコード
- ord-ae0e981c23ac413bbc517c30aa8bef53
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206128B2
反応ノート
読み込み中…