Nitric Acid → 5-Chloro-2-methyl-3-nitrobenzoic acid

HRID 1501695ノート

反応式

HRID 1501695 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[N+:12]([O-])([OH:14])=[O:13]>OS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 820095-Chloro-2-methylbenzoic acid

生成物 1

HCID 230097625-Chloro-2-methyl-3-nitrobenzoic acid収率 60%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

A stirred solution of 5-chloro-2-methylbenzoic acid (1 mmol) in conc. H2SO4 (2 mL) was cooled to −10° C. and nitrating mixture (0.4 mL of conc. H2SO4+0.1 mL of conc. HNO3) was added to it in dropwise manner. The reaction mixture was stirred at the same temperature for 20 min then warmed to room temperature. The solid precipitate was filtered and dried to obtain 5-chloro-2-methyl-3-nitrobenzoic acid which was used in next step without further purification (yield 60-70%).

後処理

  1. filtrationThe solid precipitate was filtered
  2. customdried

出典と根拠

ORDレコード
ord-bfab7be9238c446b8970d45b2006cf49
出典データセット
uspto-grants-2015_12
特許番号
US09206157B2

反応ノート

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