m-Chloroperbenzoic acid → 5-(Oxiran-2-yl)-2,1,3-benzoxadiazole
反応式
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]2=[N:7][O:8][N:9]=[C:5]2[CH:4]=1)=[CH2:2].C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[O:20]1[CH2:2][CH:1]1[C:3]1[CH:11]=[CH:10][C:6]2=[N:7][O:8][N:9]=[C:5]2[CH:4]=1参加物
4
実験手順
To a solution of 5-ethenyl-2,1,3-benzoxadiazole (1.80 g, 12.3 mmol) in DCM (20 mL) was slowly added m-CPBA (3.8 g, 22 mmol) at 0° C. The flask was warmed to room temperature; the mixture was then stirred for 12 hours. TLC as well as LC indicated that reaction had gone to completion. The mixture was washed with aqueous Na2S2O3, NaHCO3, and water. The organic layers was washed with brine and then concentrated. The residue was purified over silica gel to afford the title compound.
後処理
- customat 0° C
- customTLC as well as LC indicated that reaction
- washThe mixture was washed with aqueous Na2S2O3, NaHCO3, and water
- washThe organic layers was washed with brine
- concentrationconcentrated
- customThe residue was purified over silica gel
出典と根拠
- ORDレコード
- ord-9b1e90322f5a456fb9af78d4c1cf850a
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206199B2
反応ノート
読み込み中…