Hydrochloric Acid → 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid
反応式
O.[OH-].[Li+].[CH3:4][C:5]1[C:10]([N:11]2[CH:15]=[N:14][N:13]=[N:12]2)=[CH:9][N:8]=[C:7]([CH2:16][C:17]([O:19]C)=[O:18])[CH:6]=1.Cl>O.O1CCCC1>[CH3:4][C:5]1[C:10]([N:11]2[CH:15]=[N:14][N:13]=[N:12]2)=[CH:9][N:8]=[C:7]([CH2:16][C:17]([OH:19])=[O:18])[CH:6]=1参加物
6
実験手順
Lithium hydroxide monohydrate (19.2 mg, 0.458 mmol) was dissolved in 5 mL water then added to a methyl 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetate in tetrahydrofuran (15 mL). The reaction was stirred for 1 h then acidified with 1 N HCl to pH ˜3. The mixture was extracted with a mixture of THF/ethyl acetate (4×.). Dried over Na2SO4, filtered and evaporated concentrated to yield 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid.
後処理
- extractionThe mixture was extracted with a mixture of THF/ethyl acetate (4×.)
- dry with materialDried over Na2SO4
- filtrationfiltered
- customevaporated
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a7e62ad9af8c46e68bd17b4cca435bf3
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206199B2
反応ノート
読み込み中…