Hydrochloric Acid → Sodium hydroxide rebamipide

HRID 1502601ノート

反応式

HRID 1502601 の反応式
Cl.[CH:2]1[CH:3]=[CH:4][C:5]2[NH:12][C:10](=[O:11])[CH:9]=[C:8]([CH2:13][CH:14]([NH:18][C:19]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)=[O:20])[C:15]([OH:17])=[O:16])[C:6]=2[CH:7]=1.[OH-].[Na+:29]>O>[OH-:11].[Na+:29].[CH:2]1[CH:3]=[CH:4][C:5]2[NH:12][C:10](=[O:11])[CH:9]=[C:8]([CH2:13][CH:14]([NH:18][C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[O:20])[C:15]([OH:17])=[O:16])[C:6]=2[CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 5042Rebamipide2 回HCID 14798Sodium Hydroxide2 回

生成物 1

HCID 68327531Sodium hydroxide rebamipide

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

12 ML of 10 N hydrochloric acid (14.2 g, 0.1:2 mol), 68 mL of purified water, and 200 mL of an aqueous solution of 5% (w/v) PVPK 25 were mixed to prepare a hydrochloric acid-PVPK 25 solution. To 700 ml of an aqueous solution of sodium hydroxide which was prepared by adding purified water to 4.4 g of sodium hydroxide (0.11 mol), 20 g of rebamipide (0.054 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

後処理

  1. additionby adding
  2. additionwas added
  3. dissolutiondissolved
  4. temperaturewith heating

出典と根拠

ORDレコード
ord-be928b226ca2424fbc04de6fd884e577
出典データセット
uspto-grants-2015_12
特許番号
US09211254B2

反応ノート

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