Hydrazine hydrate (1:1) → 6-Bromophthalazin-1(2h)-one

HRID 1502709ノート

反応式

HRID 1502709 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][CH:5]2O.O.[NH2:14]N>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][N:14]=[CH:5]2

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 116155375-Bromo-3-hydroxyisoindolin-1-one

生成物 1

HCID 115359186-Bromophthalazin-1(2h)-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
95 °C

実験手順

To a stirred solution of 5-bromo-3-hydroxyisoindoline-1-one (1.0 g, 4.40 mmol) in water, was added hydrazine hydrate (0.45 g, 8.80 mmol) and heated to 95° C. for 5 h. The reaction mixture was cooled to ambient temperature, filtered and washed with diethyl ether and pentane (1:1) to afford the title compound as a white solid that was used in the next step without further purification (0.5 g): ESIMS m/z 225.15 ([M+H]+).

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. filtrationfiltered
  3. washwashed with diethyl ether and pentane (1:1)

出典と根拠

ORDレコード
ord-2798d879d6b9437090dd4a923629b71e
出典データセット
uspto-grants-2015_12
特許番号
US09210927B2

反応ノート

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