Sodium Carbonate → Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate

HRID 1503094ノート

反応式

HRID 1503094 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]([CH3:14])([CH3:13])[C:10]([O-:12])=[O:11].[CH:15]1([C:18]2[N:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=2)[CH2:17][CH2:16]1.C(=O)([O-])[O-].[Na+].[Na+].O1CCO[CH2:35][CH2:34]1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH:15]1([C:18]2[N:23]=[CH:22][C:21]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[S:8][C:9]([CH3:14])([CH3:13])[C:10]([O:12][CH2:34][CH3:35])=[O:11])=[CH:20][CH:19]=2)[CH2:17][CH2:16]1

参加物

6

反応物 4

HCID 10340Sodium CarbonateHCID 312751,4-DioxaneHCID 422050782-(2-Bromophenylthio)-2-methylpropanoateHCID 53338917(6-Cyclopropylpyridin-3-yl)boronic acid

生成物 1

HCID 54764233Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate

試薬・触媒・溶媒 1

HCID 178418397HCID 178418397、化合物触媒

反応条件

温度
80 °C

実験手順

A mixture of 2-(2-bromophenylthio)-2-methylpropanoate (1 eq), 6-cyclopropylpyridin-3-ylboronic acid (1 eq), aqueous sodium carbonate solution (2 M, 4 eq), and Pd(PPh3)4 (0.05 eq) in dioxane is degassed. The mixture is sealed, heated at 80° C., washed with water, extracted with ethyl acetate, dried (MgSO4), concentrated and purified by chromatography.

後処理

  1. customis degassed
  2. customThe mixture is sealed
  3. washwashed with water
  4. extractionextracted with ethyl acetate
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. custompurified by chromatography

出典と根拠

ORDレコード
ord-3d4bb93312c04d8f83f445f70242ea35
出典データセット
uspto-grants-2015_12
特許番号
US09212135B2

反応ノート

読み込み中…