Sodium Hydroxide → 2-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid

HRID 1503095ノート

反応式

HRID 1503095 の反応式
[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([O:20]CC)=[O:19])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([OH:20])=[O:19])=[CH:6][CH:5]=2)[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54764233Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate

生成物 1

HCID 680010602-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate (0.286 mmol) and aqueous sodium hydroxide solution (1 M, 2 mmol) in methanol is stirred at 60° C. for 12 hours. The reaction mixture is then concentrated, acidified, filtered and the isolated solid purified by to chromatography.

後処理

  1. concentrationThe reaction mixture is then concentrated
  2. filtrationfiltered
  3. customthe isolated solid purified by to chromatography

出典と根拠

ORDレコード
ord-9ffd21a163cb48e6b4e0da7568852800
出典データセット
uspto-grants-2015_12
特許番号
US09212135B2

反応ノート

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