Glyoxylic Acid → HCID 86680931、化合物

HRID 1503177ノート

反応式

HRID 1503177 の反応式
[S:1]1[CH2:5][CH:4]([C:6]([OH:8])=[O:7])[NH:3][CH:2]1[C:9]([OH:11])=O.N[C@H:13](C(O)=O)CS.C(O)(=O)C=O.S(Cl)([Cl:26])=O.[CH3:28][OH:29]>>[ClH:26].[CH3:28][O:29][C:9]([CH:2]1[NH:3][CH:4]([C:6]([O:8][CH3:13])=[O:7])[CH2:5][S:1]1)=[O:11]

参加物

6

反応物 5

HCID 760Glyoxylic AcidHCID 887MethanolHCID 5862L-(+)-CysteineHCID 24386Thionyl ChlorideHCID 72150Tidiacic

生成物 1

HCID 86680931HCID 86680931、化合物収率 94%

実験手順

Thiazolidine-2,4-dicarboxylic acid (1.00 g, 5.67 mmol) synthesized from L-cysteine and glyoxylic acid (aqueous solution) were added to a methanol solution (15 ml) of thionyl chloride (22.6 mmol), and the mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated, and to the residue was added ether. The crystals were collected by filtration, washed with ether, and dried under reduced pressure to give thiazolidine-2,4-dicarboxylic acid 2,4-dimethyl ester hydrochloride as crystals (1.29 g, 94.0%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue was added ether
  3. filtrationThe crystals were collected by filtration
  4. washwashed with ether
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-81f6adf7ed254f95881f9fe114afebb9
出典データセット
uspto-grants-2015_12
特許番号
US09212154B2

反応ノート

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