2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Ethyl 2-(4-formylphenylamino)acetate

HRID 1503643

反応式

HRID 1503643 の反応式
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([NH:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.ClC1C(=O)C(C#N)=C(C#N)C(=[O:23])C=1Cl>CO.O>[CH:14]([C:1]1[CH:6]=[CH:5][C:4]([NH:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1)=[O:23]

参加物

4

反応物 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 13263396Glycine, N-(4-methylphenyl)-, ethyl ester

生成物 1

HCID 11579360Ethyl 2-(4-formylphenylamino)acetate収率 25.1%

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

To a solution of ethyl 2-(p-tolylamino)acetate (1.69 mmol) in methanol/water (20 ml/20 ml) was added the 2,3 dichloro-5,6-dicyanobenzoquinone (2.87 mmol) and the mixture was stirred for 4 hours at room temperature. The residue was chromatographed on a silica gel column (dichloromethane/ethyl acetate 8/2 as eluent) to give 88 mg of ethyl 2-(4-formylphenylamino)acetate. (yield 25%). MS (ESI): m/z 208.0 [M+H]+

後処理

  1. customThe residue was chromatographed on a silica gel column (dichloromethane/ethyl acetate 8/2 as eluent)

出典と根拠

ORDレコード
ord-2e1bb873d548472f8c07a4805fcfef5d
出典データセット
uspto-grants-2015_12
特許番号
US09212196B2

関連ノート

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