Benzyl Alcohol → 4-[1-(4-fluorophenyl)ethoxy]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

HRID 15038

反応式

HRID 15038 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:10][C:11]2[CH:16]=[CH:15][NH:14][C:13](=[O:17])[CH:12]=2)[CH3:9])=[CH:4][CH:3]=1.C(OC1C=CN(C2C=CC([O:38][CH2:39][CH2:40][N:41]3[CH2:46][CH2:45][CH2:44][CH2:43]C3)=CN=2)C(=O)C=1)C1C=CC=CC=1.C(O)[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1.FC1C=CC(C(O)C)=CC=1.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([O:10][C:11]2[CH:16]=[CH:15][N:14]([C:52]3[CH:51]=[CH:50][C:49]([O:38][CH2:39][CH2:40][N:41]4[CH2:46][CH2:45][CH2:44][CH2:43]4)=[CH:54][CH:53]=3)[C:13](=[O:17])[CH:12]=2)[CH3:9])=[CH:6][CH:7]=1

参加物

6

反応物 5

HCID 244Benzyl AlcoholHCID 739461-(4-Fluorophenyl)ethanolHCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 589649204-benzyloxy-1-{5-[2-(1-piperidinyl)ethoxy]pyridin-2-yl}-1H-pyridin-2-oneHCID 684311724-[1-(4-fluorophenyl)ethoxy]-1H-pyridin-2-one

生成物 1

HCID 589649904-[1-(4-fluorophenyl)ethoxy]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

実験手順

Example 12 was repeated except that 4-[1-(4-fluorophenyl)ethoxy]-1H-pyridin-2-one as obtained by repeating Steps (1) and (2) of Example 1 in which benzyl alcohol was replaced with 1-(4-fluorophenyl)ethanol, was used in place of 4-benzyloxy-1H-pyridin-2-one, to provide the title compound.

後処理

  1. customas obtained

出典と根拠

ORDレコード
ord-f4d25164b2b74b7ebebb66f4dc242b34
出典データセット
uspto-grants-2010_06
特許番号
US07732456B2

関連ノート

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