Triethylsilane → 3-Chloro-1-(4-octylphenyl)propan-1-one

温度

5 °C

Octanophenone (50 g), dichloromethane (250 mL), and triethylsilane (69.77 g) are charged into a round bottom flask, stirred, and cooled to 0-10° C. Titanium tetrachloride (55.7 g) in dichloromethane (250 mL) is added to the reaction mixture over 30-35 minutes at temperature below 10° C. and the reaction mixture is stirred at a temperature of 25-30° C. for about 1 hour. The reaction mixture is filtered through a hyflo bed and washed with dichloromethane (100 mL). The filtrate obtained is charged into a second round bottom flask, aluminium chloride (41.6 g) is added, and the reaction mixture is cooled to 0-5° C. 3-Chloropropionyl chloride (30.47 g) in dichloromethane (50 mL) is added slowly to the reaction mixture at temperature below 5° C. and the reaction mixture is allowed to a temperature of 25-30° C. and maintained at the same temperature for about 1 hour. The reaction mixture is slowly added to water (500 mL) precooled to 0° C. and stirred. The organic layer is separated, washed with aqueous sodium bicarbonate solution (2×500 mL), water (500 mL), followed by brine solution (100 mL), dried over sodium sulphate and concentrated under reduced pressure at a temperature of about 45° C. to obtain 3-chloro-1-(4-octylphenyl)propan-1-one.

1. stirringthe reaction mixture is stirred at a temperature of 25-30° C. for about 1 hour
2. filtrationThe reaction mixture is filtered through a hyflo bed
3. washwashed with dichloromethane (100 mL)
4. customThe filtrate obtained
5. additionis charged into a second round bottom flask
6. temperaturethe reaction mixture is cooled to 0-5° C
7. customis allowed to a temperature of 25-30° C.
8. temperaturemaintained at the same temperature for about 1 hour
9. customprecooled to 0° C.
10. stirringstirred
11. customThe organic layer is separated
12. washwashed with aqueous sodium bicarbonate solution (2×500 mL), water (500 mL)
13. dry with materialdried over sodium sulphate
14. concentrationconcentrated under reduced pressure at a temperature of about 45° C.

ORDレコード

ord-bfb544fc54d04464800d70d100624b64

出典データセット

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09216943B2