HCID 67235239、化合物 → HCID 67235719、化合物

HRID 1505324ノート

反応式

HRID 1505324 の反応式
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[N:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

参加物

4

反応物 1

HCID 67235239HCID 67235239、化合物2 回

生成物 1

HCID 67235719HCID 67235719、化合物収率 93.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-({3-[(1-methylethyl)oxy]phenyl}oxy)-5-nitropyridine (Intermediate 28, 670 mg, 2.45 mmol) in methanol (50 mL) was added Pd/C (10%, 100 mg, 0.1 wet. e.g.) and the flask was filled in with H2. The resulting mixture was stirred at room temperature under H2 atmosphere overnight and filtered. The filtrate was concentrated under vacuum to afford the title compound as a brown solid (560 mg).

後処理

  1. additionthe flask was filled in with H2
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-9fab902458bc4fceb25c2ef4fc03254a
出典データセット
uspto-grants-2015_12
特許番号
US09216967B2

反応ノート

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