Trifluoroacetic acid → HCID 67235885、化合物

HRID 1505341ノート

反応式

HRID 1505341 の反応式
[CH3:1][C@@H:2]([NH:22]C(=O)OC(C)(C)C)[C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([O:20][CH3:21])[CH:14]=2)=[CH:10][CH:11]=1)=[O:4].C(O)(C(F)(F)F)=O>ClCCl>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:9]2[N:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[C@@H:2]([CH3:1])[NH2:22])=[CH:11][CH:10]=2)=[CH:14][C:15]=1[O:20][CH3:21]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 710067841,1-dimethylethyl {(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate2 回

生成物 1

HCID 67235885HCID 67235885、化合物収率 98.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1,1-dimethylethyl {(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate (Intermediate 51, 350 mg) in dry dichloromethane (7.5 mL), TFA (2.5 mL, 32.4 mmol) was slowly added and the reaction mixture was stirred for 1.5 hours at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified with an SCX cartridge (10 g) to afford the title compound as a colourless oil (258 mg).

後処理

  1. customThe solvent and the excess of TFA were evaporated
  2. customthe residue was purified with an SCX cartridge (10 g)

出典と根拠

ORDレコード
ord-20e3c46e54714a2eb530123888ffbbbd
出典データセット
uspto-grants-2015_12
特許番号
US09216967B2

反応ノート

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