Trifluoroacetic acid → HCID 67235286、化合物
反応式
[CH3:1][CH:2]([CH3:31])[C@@H:3]([NH:23]C(=O)OC(C)(C)C)[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([O:21][CH3:22])[CH:15]=2)=[CH:9][CH:8]=1)=[O:5].C(O)(C(F)(F)F)=O>ClCCl>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][C:10]2[CH:11]=[CH:12][C:7]([NH:6][C:4](=[O:5])[C@@H:3]([CH:2]([CH3:31])[CH3:1])[NH2:23])=[CH:8][CH:9]=2)=[CH:15][C:16]=1[O:21][CH3:22]参加物
4
実験手順
To a solution of 1,1-dimethylethyl ((1R)-2-methyl-1-{[(4-{[4-methyl-3-(methyloxy)phenyl]oxy}phenyl)amino]carbonyl}propyl)carbamate (Intermediate 82, 110 mg) in dry dichloromethane (3 mL), TFA (1 mL, 12.98 mmol) was added and the reaction mixture was stirred for 1 hour at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified by SCX cartridge (5 g) to afford the title compound as a yellow pale solid (68 mg).