Ethanol → HCID 67609650、化合物
反応式
[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].[CH2:13]([OH:15])[CH3:14].[Br:16]N1C(=O)CCC1=O>ClCCl>[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1([Br:16])[CH2:11][CH2:10][O:9][CH:8]1[O:15][CH2:13][CH3:14])=[O:6])[CH3:2]参加物
5
反応条件
- 温度
- 7.5 °C
実験手順
Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (VI, 100 g) was dissolved in dichloromethane (500 ml) and Ethanol (150 mL) was added. The reaction mass was cooled to 5 to 10° C. N-bromosuccinimide (115 g) was added lot wise by maintaining temp below 10° C. Reaction mass was then stirred at 20-30° C. till completion of reaction. Reaction mass was washed with sodium bicarbonate solution (2%, 3×400 mL) and the organic layer was used for the next step.
後処理
- temperatureby maintaining temp below 10° C
- customReaction mass
- customReaction mass
- washwas washed with sodium bicarbonate solution (2%, 3×400 mL)
出典と根拠
- ORDレコード
- ord-690d85a9c3564f12b60904e039a473ed
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09216990B2
反応ノート
読み込み中…