Ethanolamine → Palmitoylethanolamide

HRID 1506728

反応式

HRID 1506728 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5](OC=C)(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C[O-].[Na+]>>[C:5]([NH:4][CH2:3][CH2:1][OH:2])(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

4

反応物 3

HCID 700EthanolamineHCID 69658Hexadecanoic acid, ethenyl esterHCID 10942334Sodium Methoxide

生成物 1

HCID 4671Palmitoylethanolamide

実験手順

In an exemplary embodiment, 20 mmol ethanolamine was reacted with 1 mmol vinyl stearate at 80° C. for 1 hour in the presence of 1% sodium methoxide. N-stearoylethanolamine with 96% purity was obtained after the removal of excess ethanolamine without further purification. In another exemplary embodiment, 20 mmol ethanolamine was reacted with 1 mmol vinyl palmitate at 60° C. for 1.5 hours in the presence of 1% sodium methoxide. N-palmitoylethanolamine with 98% purity was obtained after the removal of excess ethanolamine without further purification. More examples of reacting the alkanolamine and the vinyl ester of the fatty acid to prepare the high-purity fatty acid N-acylalkanolamine in a high yield are described in Examples 1-8.

後処理

  1. customafter the removal of excess ethanolamine
  2. customwithout further purification

出典と根拠

ORDレコード
ord-87077d1c2c5f4de8b2fbb1eea084ec2f
出典データセット
uspto-grants-2015_12
特許番号
US09221747B2

関連ノート

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