Sodium Hydroxide → 3-(Pyridin-2-yl)benzoic acid

HRID 1507036ノート

反応式

HRID 1507036 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12]C)=[O:11].[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([OH:12])=[O:11]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 3364101Methyl 3-(pyridin-2-yl)benzoate

生成物 1

HCID 51525923-(Pyridin-2-yl)benzoic acid収率 93%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 3-(pyridin-2-yl)benzoate (400 mg, 1.88 mmol) in MeOH (3 mL) was added aqueous of NaOH (1 mL, 40 mol %). The reaction mixture was stirred at room temperature for 3 h and concentrated. The crude residue was dissolved in water and the pH was adjusted to 5˜6 with 2N of HCl. The solution was extracted with ethyl acetate, brine, dried over sodium sulfate, filtered and concentrated. (350 mg, yield 93%) MS (ESI+) e/z: 200.1 [M+1]+.

後処理

  1. concentrationconcentrated
  2. dissolutionThe crude residue was dissolved in water
  3. extractionThe solution was extracted with ethyl acetate, brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-a89da6cea659468590adb1164a31b108
出典データセット
uspto-grants-2015_12
特許番号
US09221794B2

反応ノート

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