Hydrochloric Acid → HCID 90047521、化合物

反応式

C([NH:8][C:9]1[N:14]=[C:13]2[N:15]([CH3:21])[C:16](=[O:20])[C:17]([CH3:19])([CH3:18])[C:12]2=[CH:11][CH:10]=1)C1C=CC=CC=1.[ClH:22]>C(O)C.[Pd]>[ClH:22].[NH2:8][C:9]1[N:14]=[C:13]2[N:15]([CH3:21])[C:16](=[O:20])[C:17]([CH3:18])([CH3:19])[C:12]2=[CH:11][CH:10]=1

参加物

反応条件

温度: 40 °C

実験手順

A mixture of 6-(benzylamino)-1,3,3-trimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (610 mg, 2.17 mmol) and 25% aqueous HCl solution (1.2 g, 1 ml, 8.23 mmol) in ethanol (20 ml) was evacuated three times and flushed with argon. Pd (10% on activated charcoal, 231 mg, 217 μmol) was added. Degassing was repeated, then evacuated three times and flushed with hydrogen. The reaction mixture was heated to 40° C. and stirred 4 hours at this temperature under the hydrogen atmosphere. The reaction mixture was filtered through a glass fiber filter, washed with EtOH and the solvent was evaporated. The title compound was obtained as grey solid (388 mg) and was used without further purification.