Triethylamine → 3-Bromo-2-chloro-6-fluorobenzonitrile

HRID 1508171ノート

反応式

HRID 1508171 の反応式
[Br:1][C:2]1[C:3]([Cl:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]([NH2:7])=O.CCN(CC)CC.FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O>C(Cl)Cl>[Br:1][C:2]1[C:3]([Cl:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]#[N:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 712395033-Bromo-2-chloro-6-fluorobenzamide

生成物 1

HCID 712393913-Bromo-2-chloro-6-fluorobenzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-bromo-2-chloro-6-fluorobenzamide (3.56 mmol) in 50 mL DCM were added 1.5 mL Et3N followed by trifluoromethanesulfonic acid anhydride (7.11 mmol) at 0° C. The ice bath was removed and the reaction mixture was stirred at RT. After 30 min, water was added and the mixture was extracted with DCM (3×). The combined organic layers were dried over MgSO4 and concentrated in vacuo to obtain the desired compound as brown solid.

後処理

  1. customThe ice bath was removed
  2. additionwater was added
  3. extractionthe mixture was extracted with DCM (3×)
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0417eee7762a4333be31dc3b00dc285b
出典データセット
uspto-grants-2015_12
特許番号
US09221832B2

反応ノート

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