furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime → 5,6-Dihydrofuro[2,3-c]pyridazin-5-amine
反応式
CO[N:3]=[C:4]1[C:12]2[CH:11]=[CH:10][N:9]=[N:8][C:7]=2[O:6][CH2:5]1>N.CO.[Pd]>[N:8]1[C:7]2[O:6][CH2:5][CH:4]([NH2:3])[C:12]=2[CH:11]=[CH:10][N:9]=1参加物
5
実験手順
To a solution of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (1.35 mmol) in 10 mL 7N NH3 in MeOH was added Pd/C (50 mg) and the reaction mixture was stirred under a H2 atmosphere for 1 h. The mixture was then filtered over Celite, washed with 20 mL MeOH and concentrated in vacuo to give the title compound as dark red oil;
後処理
- filtrationThe mixture was then filtered over Celite
- washwashed with 20 mL MeOH
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-6c710458a2554d5ebc554f8bf03aee8f
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221832B2
反応ノート
読み込み中…