Sodium Hydroxide → (3S)-1-(2-fluoroethyl)-3-hydroxypyrrolidine
反応式
[OH-].[Na+].[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([O:11]C(=O)C)[CH2:7]1>CO>[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([OH:11])[CH2:7]1参加物
4
実験手順
4N aqueous sodium hydroxide solution (2 mL) was added to methanol (10 mL) solution of (3S)-1-(2-fluoroethyl)-3-acetoxypyrrolidine (507 mg, 2.89 mmols), and stirred at room temperature for an hour. The reaction liquid was concentrated under reduced pressure, extracted with chloroform and dried over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the title compound (135 mg, 35%) was obtained.
後処理
- customThe reaction liquid
- concentrationwas concentrated under reduced pressure
- extractionextracted with chloroform
- dry with materialdried over anhydrous sodium sulfate
- concentrationConcentrating
- customthe reaction liquid under reduced pressure
出典と根拠
- ORDレコード
- ord-760412e2ac6c4faea17af6eff13e4d41
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732456B2
反応ノート
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