Hydrazine → 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazole-3(2H)-carbothioamide

HRID 1508400ノート

反応式

HRID 1508400 の反応式
[N:1]([CH2:4][CH2:5][CH2:6][C:7]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:11]([C:12]([NH:14]C(=O)C2C=CC=CC=2)=[S:13])[N:10]=[C:9]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[F:30])[S:8]1)=[N+:2]=[N-:3].NN>C1COCC1>[N:1]([CH2:4][CH2:5][CH2:6][C:7]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:11]([C:12](=[S:13])[NH2:14])[N:10]=[C:9]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[F:30])[S:8]1)=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 9321HydrazineHCID 86608769N-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole-3-carbonothioyl)benzamide

生成物 1

HCID 866087702-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazole-3(2H)-carbothioamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of N-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole-3-carbonothioyl)benzamide (0.737 g, 1.41 mmol) in 20 mL of anhydrous THF was added hydrazine (0.088 mL, 2.82 mmol). The reaction was stirred at room temperature for 3 hours, then concentrated in vacuo. The residue was purified by flash column chromatography (10-20% ethyl acetate/hexanes) to afford the desired product as a pale yellow foam, 0.504 g, 85%.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by flash column chromatography (10-20% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-e169d5e1c5ba44b78a06b623de55a9ae
出典データセット
uspto-grants-2015_12
特許番号
US09221841B2

反応ノート

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