Diethyl Oxalate → Ethyl 3-(4-chlorophenyl)-2-oxopropanoate

HRID 1508425ノート

反応式

HRID 1508425 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[Cl:16]C1C=CC(CCl)=CC=1.[Mg].C(OCC)(=O)C(OCC)=O>>[Cl:16][C:6]1[CH:5]=[CH:4][C:3]([CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:2][CH:7]=1

参加物

5

反応物 4

HCID 7268Diethyl OxalateHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 5462224MagnesiumHCID 18370709Ethyl (2-fluorophenyl)pyruvate

生成物 1

HCID 2736395Ethyl 3-(4-chlorophenyl)-2-oxopropanoate収率 74%

実験手順

The title compound was prepared as described for B4 using 4-chlorobenzyl chloride (1.250 g, 7.76 mmol), magnesium (0.208 g, 8.54 mmol) and diethyl oxalate (2.269 g, 15.53 mmol). The product was isolated in the form of colorless oil in 74% yield and used instantly in next step.

後処理

  1. customThe product was isolated in the form of colorless oil in 74% yield

出典と根拠

ORDレコード
ord-051a419eefb04280a55486f94d144d82
出典データセット
uspto-grants-2015_12
特許番号
US09221860B2

反応ノート

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