Sodium borohydride → HCID 64515792、化合物

HRID 1508543ノート

反応式

HRID 1508543 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10]2)=[CH:5][CH:4]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 140909103-(4-Methoxyphenyl)cyclopentan-1-one

生成物 1

HCID 64515792HCID 64515792、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a RT solution of 3-(4-methoxyphenyl)cyclopentanone (Step B) (482.5 mg, 2.54 mmol) in MeOH (5 ml) was added sodium borohydride (96 mg, 2.54 mmol). The reaction mixture was stirred under nitrogen for 30 minutes, then, concentrated, added water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and the solvent was evaporated under reduced pressure to afford the title compound as a mixture of diastereomers that was used without further purification. Mass spectrum (ESI) 175.3 (M+1 minus 18).

後処理

  1. concentrationconcentrated
  2. additionadded water
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-59762882a45a47dba9bb864048a8fad0
出典データセット
uspto-grants-2015_12
特許番号
US09221834B2

反応ノート

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