Sodium borohydride → Veonetinib

HRID 1510105ノート

反応式

HRID 1510105 の反応式
[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][N:27]4[CH2:33][C:32](=[O:34])[C:29]5([CH2:31][CH2:30]5)[CH2:28]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:35])[NH:6]2.[BH4-].[Na+]>CO>[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][N:27]4[CH2:33][CH:32]([OH:34])[C:29]5([CH2:31][CH2:30]5)[CH2:28]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:35])[NH:6]2

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 461764815-(2-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-one

生成物 1

HCID 46176482Veonetinib収率 79.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The above product from Example 2 (75 mg) was dissolved into MeOH (8 ml) and stirred at RT. NaBH4 (75 mg) was added to the reaction and stirred at RT for 30 min. The reaction was evaporated and purified by column chromatography to give title compound (60 mg). Mass: (M+1), 478

後処理

  1. stirringstirred at RT for 30 min
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

出典と根拠

ORDレコード
ord-b7948eb6f2c34b8abef886925e5ac23b
出典データセット
uspto-grants-2012_07
特許番号
US08211911B2

反応ノート

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