Dichloromethane → (3-Isopropoxyphenyl)methanol

HRID 1510151ノート

反応式

HRID 1510151 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+].C(Cl)Cl>CO>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6344Dichloromethane2 回HCID 7129143-IsopropoxybenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 2759474(3-Isopropoxyphenyl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 1 molar solution of 3-isopropoxy benzaldehyde (102 g, 0.621 moles) in methanol (620 mL) cooled to 0° was added (slowly) sodium borohydride powder (25.8 g, 0.683 moles)-dissolved in a minimum of methylene chloride and passed through a plug of silica gel washing with more methylene chloride until the silica gel was free of the product. The eluent was stripped to an oil and pumped on high vacuum overnight.

後処理

  1. custompumped on high vacuum overnight

出典と根拠

ORDレコード
ord-bb2baadfd4414e958c89bb400d2de812
出典データセット
uspto-grants-2012_07
特許番号
US08211904B2

反応ノート

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