Potassium Carbonate → HCID 66790112、化合物

HRID 1510159ノート

反応式

HRID 1510159 の反応式
[CH:1]([CH:3]1[CH2:8][C:7](=[O:9])[CH2:6][CH2:5][NH:4]1)=[CH2:2].Cl[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH:19]([CH3:21])[CH3:20])[CH:13]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH:19]([O:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[CH2:11][N:4]1[CH2:5][CH2:6][C:7](=[O:9])[CH2:8][CH:3]1[CH:1]=[CH2:2])([CH3:21])[CH3:20]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 205693092-Ethenylpiperidin-4-oneHCID 295411551-(Chloromethyl)-3-isopropoxybenzene

生成物 1

HCID 66790112HCID 66790112、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

2-vinylpiperidin-4-one (4.85 g, 38.7 mmol) in acetonitrile (40 ml) was added 1-(chloromethyl)-3-isopropoxybenzene (7.16 g, 38.7 mmol) and finely ground K2CO3 (16.1 g, 116 mmol). The mixture was stirred at 60° C. for 12 hrs. The solution was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 65i, eluting with 15% ethyl acetate/hexanes.

後処理

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel Biotage 65i
  4. washeluting with 15% ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-9f5efcdc2e394b4b9bb9b8bb13a10979
出典データセット
uspto-grants-2012_07
特許番号
US08211904B2

反応ノート

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