Toluene → 2-(2-Methoxyphenyl)naphthalene

HRID 1510182

反応式

HRID 1510182 の反応式
C1COCC1.[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[Mg]Br.Cl[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26].C1(C)C=CC=CC=1>CCCCCC>[CH3:26][O:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:7]1[CH:8]=[CH:9][C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=1

参加物

6

反応物 4

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 130112-ChloroanisoleHCID 178418423HCID 178418423、化合物

生成物 1

HCID 111606562-(2-Methoxyphenyl)naphthalene収率 96%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Using a THF solution of 2-naphthylmagnesium bromide (1.47 mL, 1.02 M, 1.5 mmol), and 1-chloro-2-methoxybenzene (142.6 mg, 1.0 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 70° C. for 48 hours in the same manner as in Example 2. After performing silica gel column chromatography (toluene=10, 20 and 40% in hexane), the above compound was obtained as a white solid (0.224 g, yield=96%, purity=>99% (GC analysis)).

後処理

  1. customthe above compound was obtained as a white solid (0.224 g, yield=96%, purity=>99% (GC analysis))

出典と根拠

ORDレコード
ord-37c1d50c0e144af5adab41ca0d0d5980
出典データセット
uspto-grants-2012_07
特許番号
US08211820B2

関連ノート

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