反応式
C(=O)([O-])[O-].[Cs+].[Cs+].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.Br[C:54]1[CH:59]=[CH:58][C:57]([CH2:60][NH:61][C:62]([CH:64]2[CH2:69][CH2:68][CH2:67][CH:66]([NH:70][C:71]3[N:76]=[C:75]([CH3:77])[N:74]=[C:73]([NH:78][CH3:79])[N:72]=3)[CH2:65]2)=[O:63])=[C:56]([Cl:80])[CH:55]=1.[NH:81]1[CH2:86][CH2:85][CH2:84][CH2:83][CH2:82]1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1>[Cl:80][C:56]1[CH:55]=[C:54]([N:81]2[CH2:86][CH2:85][CH2:84][CH2:83][CH2:82]2)[CH:59]=[CH:58][C:57]=1[CH2:60][NH:61][C:62]([C@H:64]1[CH2:69][CH2:68][CH2:67][C@@H:66]([NH:70][C:71]2[N:76]=[C:75]([CH3:77])[N:74]=[C:73]([NH:78][CH3:79])[N:72]=2)[CH2:65]1)=[O:63]参加物
反応物 4
生成物 1
試薬・触媒・溶媒 2
反応条件
- 温度
- 100 °C
実験手順
In a microwave reaction vessel was added cesium carbonate (0.049 g, 0.150 mmol) under nitrogen. Next, Pd2(dba)3 (4.89 mg, 5.34 μmol), BINAP (4.99 mg, 8.02 μmol), N-[(4-bromo-2-chlorophenyl)methyl]-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide (0.050 g, 0.107 mmol) and piperidine (10.58 μl, 0.107 mmol) were then added to the reaction vial. Toluene (4.00 ml) was added and the reaction was heated to 100° C. for 16 hours. LCMS showed the formation of the desired product and the consumption of the starting materials. The reaction was cooled, the solvent was removed under vacuum, and the residue was purified by preparative HPLC to provide cis-N-{[2-chloro-4-(1-piperidinyl)phenyl]methyl}-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide (19 mg, 0.032 mmol, 30%). MS (ES+): m/e 472, 474 [M+H]+.
後処理
- customIn a microwave reaction vessel
出典と根拠
- ORDレコード
- ord-fb0823ee512d4b278a2d7bcf3adb218c
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08212032B2
関連ノート
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