Lithium Hydroxide → 2-Ethylpyridin-3-ol
反応式
C([O:4][C:5]1[C:6]([CH2:11][CH3:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=O)C.[Li+].[OH-]>C(O)C>[CH2:11]([C:6]1[C:5]([OH:4])=[CH:10][CH:9]=[CH:8][N:7]=1)[CH3:12]参加物
4
実験手順
To a solution of 2-ethylpyridin-3-yl acetate (5.1 g, 31 mmol) in ethanol (50 mL) was added 3M LiOH (50 mL, 150 mmol). The reaction mixture stirred at ambient temperature for 30 minutes. The mixture was concentrated to dryness and purified over silica gel (10% MeOH in CH2Cl2) to afford 2-ethylpyridin-3-ol (2.5 g, 20 mmol).
後処理
- concentrationThe mixture was concentrated to dryness
- custompurified over silica gel (10% MeOH in CH2Cl2)
出典と根拠
- ORDレコード
- ord-8bfd3a82531f4e92b93367656bc76af4
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08212045B2
反応ノート
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