6-Bromo-1-hexene → N-[(Hex-5-en-1-yl)(propan-2-yl)carbamoyl]-3-methyl-L-valine

反応式

[CH:1]([N:4]([CH2:16][CH2:17][CH2:18][CH:19]=[CH2:20])[C:5]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[C:9]([CH3:12])([CH3:11])[CH3:10])=[O:6])([CH3:3])[CH3:2].Br[CH2:22]CCCC=C>>[CH2:16]([N:4]([CH:1]([CH3:2])[CH3:3])[C:5]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[C:9]([CH3:12])([CH3:11])[CH3:10])=[O:6])[CH2:17][CH2:18][CH2:19][CH:20]=[CH2:22]

参加物

反応物 2

HCID 759066-Bromo-1-hexene

HCID 576926803-Methyl-N-[(pent-4-en-1-yl)(propan-2-yl)carbamoyl]-L-valine

生成物 1

HCID 59856486N-[(Hex-5-en-1-yl)(propan-2-yl)carbamoyl]-3-methyl-L-valine

実験手順

N-{[Hex-5-en-1-yl(isopropyl)amino]carbonyl}-3-methyl-L-valine was prepared according to the procedure described for N-{[isopropyl(pent-4-en-1-yl)amino]carbonyl}-3-methyl-L-valine by using 6-bromo-1-hexene in Step 1. LRMS (ESI) m/z 299 [(M+H)+; calcd for C16H31N2O3: 299.2].

出典と根拠

ORDレコード: ord-cf75495a73d8422cb11fa16ee52bd1ee
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08216999B2

反応ノート

読み込み中…

参加物