2-Thiophenecarboxaldehyde → N-(2-Thienylmethyl)-β-alanine ethyl ester
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.C(N(CC)CC)C.Cl.[NH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].[BH4-].[Na+]>CO>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]参加物
6
実験手順
2-Thiophene aldehyde (11.2 g) was dissolved in 100 mL of methanol, then 12.1 g of triethylamine and 16.1 g of ethyl 3-aminopropionate hydrochloride were added thereto in this order and the mixture was stirred overnight at room temperature. The reaction solution was cooled down to 0° C., 2.27 g of sodium borohydride was slowly added thereto little by little and the mixture was stirred at room temperature for 1 hour.
後処理
- temperatureThe reaction solution was cooled down to 0° C.
- stirringlittle by little and the mixture was stirred at room temperature for 1 hour
出典と根拠
- ORDレコード
- ord-bfd4f80a6bf3423fb385279c8056c432
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08217031B2
反応ノート
読み込み中…