2-(2-Dimethylaminoethoxy)-5-nitropyridine → 6-[2-(Dimethylamino)ethoxy]pyridin-3-amine

HRID 1512102ノート

反応式

HRID 1512102 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])=[N:8][CH:9]=1)([O-])=O.[H][H]>CO.[Pd]>[CH3:14][N:13]([CH3:15])[CH2:12][CH2:11][O:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 529049082-(2-Dimethylaminoethoxy)-5-nitropyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 206914066-[2-(Dimethylamino)ethoxy]pyridin-3-amine収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-(5-Nitropyridin-2-yloxy)-N,N-dimethylethanamine (295 mg, 1.40 mmol) was dissolved in 5 mL of methanol and placed under a nitrogen atmosphere. A catalytic amount of 10% palladium on carbon was added and a hydrogen balloon was connected to the reaction flask. The flask was flushed five times with hydrogen and stirred at room temperature under hydrogen atmosphere for 16 hours. The solid was filtered and washed with methanol. The filtrate was evaporated under reduced pressure yielding 6-[2-(dimethylamino)ethoxy]pyridin-3-amine as a brown oil (250 mg, 99%). LC/MS (m/z): 182.1 (MH+), Rt 0.36 minutes.

後処理

  1. customThe flask was flushed five times with hydrogen
  2. filtrationThe solid was filtered
  3. washwashed with methanol
  4. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6d36d18db29343cdaac6c9c4545724fb
出典データセット
uspto-grants-2012_07
特許番号
US08217035B2

反応ノート

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