4-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole → HCID 66577235、化合物

HRID 1512615ノート

反応式

HRID 1512615 の反応式
[CH:1]([Mg]Br)=[CH2:2].Br[CH2:6][C:7]1[C:8]([CH3:19])=[N:9][O:10][C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1>C1COCC1.[Cu]I>[CH2:6]([C:7]1[C:8]([CH3:19])=[N:9][O:10][C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)[CH:1]=[CH2:2]

参加物

5

反応物 2

HCID 665772234-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazoleHCID 178418507HCID 178418507、化合物

生成物 1

HCID 66577235HCID 66577235、化合物

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-40 °C

実験手順

Copper(I) iodide (0.187 g, 0.98 mmol) was suspended in THF (43 mL) then cooled to −40° C. under N2 atmosphere. Vinylmagnesium bromide (1 M in THF, 9.74 mL, 9.74 mmol) was added over the course of 4 minutes and the reaction continued stirring for 18 minutes. Next, 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole (2.15 g, 6.5 mmol) in THF (11 mL) was added over the course of 15 minutes. The reaction was placed in a −20° C. overnight. After warming the reaction was submitted to standard aqueous workup to afford the title compound.

後処理

  1. waitThe reaction was placed in a −20° C. overnight
  2. temperatureAfter warming the reaction

出典と根拠

ORDレコード
ord-993c34c2e2cc4ed991da22fcb90c3380
出典データセット
uspto-grants-2012_07
特許番号
US08217066B2

反応ノート

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