Sodium Iodide → HCID 66577474、化合物

HRID 1512640ノート

反応式

HRID 1512640 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.Br[C:17]([F:21])([F:20])[CH:18]=[CH2:19].[In].[I-].[Na+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[C:17]([F:21])([F:20])[CH:18]=[CH2:19])=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 5550853-bromo-3,3-difluoroprop-1-eneHCID 5359967IndiumHCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde

生成物 1

HCID 66577474HCID 66577474、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.511 g, 1.92 mmol), 3-bromo-3,3-difluoro-propene (0.4977 g, 3.07 mmol), indium (0.357 g, 3.07 mmol) and sodium iodide (0.0142 g, 0.096 mmol) were combined in DMF (5 mL) and stirred at room temperature overnight. The reaction mixture was submitted to standard aqueous workup to afford the title compound, which was taken to the next step without further purification.

出典と根拠

ORDレコード
ord-e6a8ad9c6ca8477a9e786cabf7114cf0
出典データセット
uspto-grants-2012_07
特許番号
US08217066B2

反応ノート

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