2-(hydroxymethyl)-1H-indole-5-carbonitrile → 2-formyl-1H-indole-5-carbonitrile
反応式
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][CH:6]=2>ClCCl.O=[Mn]=O>[CH:2]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][CH:6]=2)=[O:1]参加物
4
実験手順
MnO2 (1.76 g) was added to a solution of 2-(hydroxymethyl)-1H-indole-5-carbonitrile (D24) (290 mg) in dichloromethane (100 mL) at RT. The reaction mixture was stirred at RT for 1 hour. The solid was filtered off and washed with dichloromethane. The filtrate was concentrated to afford 2-formyl-1H-indole-5-carbonitrile (D28) (230 mg) as a white solid. MS (ES): C10H6N2O requires 170; found 169.1 (M−H+).
後処理
- filtrationThe solid was filtered off
- washwashed with dichloromethane
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-3ba200123d094626990593699608c7bf
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08217028B2
反応ノート
読み込み中…