Water → 2-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

HRID 1512967ノート

反応式

HRID 1512967 の反応式
[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4]O.S(Cl)([Cl:15])=O.O>C1(C)C=CC=CC=1>[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4][Cl:15]

参加物

5

反応物 3

HCID 962WaterHCID 24386Thionyl ChlorideHCID 38708672,3-Difluoro-6-methoxybenzyl alcohol

生成物 1

HCID 593096112-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 2,3-difluoro-6-methoxybenzyl alcohol (6.97 g) in toluene (100 mL) was added thionyl chloride (4.4 mL) in a dropwise manner at room temperature, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine twice, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (7.65 g).

後処理

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water and brine twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-c7ea50b9d7aa45b38bc8f6f1ea5d9a4e
出典データセット
uspto-grants-2012_07
特許番号
US08217069B2

反応ノート

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