Trifluoroacetic acid → Trifluoroacetic acid
反応式
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)=[O:23])=[CH:17][CH:16]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49]>ClCCl>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=4)=[O:23])=[CH:19][CH:20]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([OH:41])=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[C:48]([OH:50])([C:47]([F:52])([F:51])[F:46])=[O:49]参加物
5
実験手順
Tert-butyl 2-(1-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-(3-pyridin-4-ylureido)phenyl)-1,3,5-triazin-2-yl)piperidin-4-ylamino)acetate (28 mg) in dichloromethane (3 mL) was treated with trifluoroacetic acid (1 mL) and then concentrated to dryness to give the title compound as its TFA salt.