反応式
[F:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[C:7]([F:16])[C:8](=[O:15])[N:9]3CC(=C)C=1[C:10]=23.S([O-])([O-])=O.[Na+].[Na+].[C:23]([OH:27])([CH3:26])([CH3:25])[CH3:24].[OH2:28]>>[F:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[C:7]([F:16])[C:8](=[O:15])[N:9]3[CH2:25][C:23]([OH:27])([CH2:26][OH:28])[C:24]=1[C:10]=23参加物
4
実験手順
A solution of 3,8-difluoro-4-methylidene-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one (631 mg, 2.9 mmol) in tert-butanol/water (30 ml/30 ml) was treated with AD mix alpha (4.3 g) under argon. After 18 hours stirring the reaction mixture was treated with saturated sodium sulphite solution (30 ml). After 10 minutes stirring the mixture was extracted with 20% methanol in dichloromethane (3×300 ml). The organic extracts were dried over magnesium sulphate and evaporated affording a white solid (710 mg, 97%).
後処理
- additionmix alpha (4.3 g) under argon
- stirringAfter 10 minutes stirring the mixture
- extractionwas extracted with 20% methanol in dichloromethane (3×300 ml)
- dry with materialThe organic extracts were dried over magnesium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-c9aded2d0f824bf9b94d7c7d4dcc8f67
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732460B2
関連ノート
読み込み中…