p-Chlorophenacyl bromide → 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

HRID 1514

反応式

HRID 1514 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=O.C[O:13][C:14]([NH:16][NH2:17])=[S:15]>C(#N)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[CH2:2][S:15][C:14](=[O:13])[NH:16][N:17]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 68303p-Chlorophenacyl bromideHCID 10171237O-methyl hydrazinecarbothioate

生成物 1

HCID 3294735-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one収率 48.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).

後処理

  1. temperaturewas refluxed overnight
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe light yellow solid was washed with hexane
  5. customdried

出典と根拠

ORDレコード
ord-3b6843caea374b8d88ee79ad8d8db495
出典データセット
uspto-grants-1998_03
特許番号
US05726162

関連ノート

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