Hydrazine hydrate (1:1) → m-Bromobenzohydrazide

After 10 grams (44 mmol) of ethyl-3-bromobenzoate were placed into a 200 mL, three-neck flask, 50 mL of ethanol was added thereto and the mixture was stirred; 12 mL of hydrazine monohydrate was added, this mixture was stirred at 78° C. for 5 hours, and the contents of the flask were reacted together. After the reaction was completed, a solid was precipitated out with the addition of water to the reaction solution. The precipitate solid was removed by suction filtration. With the suction-filtered solid being placed into approximately 500 mL of water and washed and a solid removed by suction filtration, 8.1 grams of a white-colored solid, which was the objective of the synthesis process, were obtained at a yield of 86%.

1. additionwas added
2. stirringthis mixture was stirred at 78° C. for 5 hours
3. customthe contents of the flask were reacted together
4. customa solid was precipitated out with the addition of water to the reaction solution
5. customThe precipitate solid was removed by suction filtration
6. washwashed
7. customa solid removed by suction filtration, 8.1 grams of a white-colored solid, which
8. customwere obtained at a yield of 86%

ORDレコード

ord-c3be112600ce4a58aee544efac0496bb

出典データセット

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08221904B2