Hydrogen Bromide → HCID 59403478、化合物

反応式

C[O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1.Br>>[OH:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 598978568-Methoxy-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

生成物 1

HCID 59403478HCID 59403478、化合物収率 117%

反応条件

温度: 110 °C

実験手順

A mixture of 8-(methyloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (Preparation 25) (7.98 g, 41.3 mmol) and hydrobromic acid (100 ml, 1842 mmol) was stirred and heated at 110° C. for 7 hours. Then the reaction mixture was evaporated and azeotroped twice with 150 ml of ethanol to give the title compound (8.66 g) light brown solid which was used without purification. MS (ES) C9H9NO3 requires 179; found 180 [M+H]+.

後処理

customThen the reaction mixture was evaporated
customazeotroped twice with 150 ml of ethanol

出典と根拠

ORDレコード: ord-8e86bd5396de46cf86608ab125613222
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08222245B2

反応ノート

読み込み中…

参加物