1,1-dimethylethyl 9-[(phenylmethyl)oxy]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate → tert-butyl 9-hydroxy-2,3-dihydrobenzo[f][1,4]oxazepine-4(5H)-carboxylate

HRID 1514223ノート

反応式

HRID 1514223 の反応式
C1(C[O:8][C:9]2[C:19]3[O:18][CH2:17][CH2:16][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:14][C:13]=3[CH:12]=[CH:11][CH:10]=2)C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[C:19]2[O:18][CH2:17][CH2:16][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:14][C:13]=2[CH:12]=[CH:11][CH:10]=1

参加物

4

反応物 1

HCID 594034471,1-dimethylethyl 9-[(phenylmethyl)oxy]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

生成物 1

HCID 59403444tert-butyl 9-hydroxy-2,3-dihydrobenzo[f][1,4]oxazepine-4(5H)-carboxylate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 1,1-dimethylethyl 9-[(phenylmethyl)oxy]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 61) (8.25 g, 23.21 mmol) in ethanol (100 ml) was hydrogenated with 10% palladium on carbon (0.825 g, 7.75 mmol) for 18 hours, filtered and evaporated to give 6.16 g of white solid. MS (ES−): C21H25NO4 requires 265; found 264 [M−H+].

後処理

  1. filtrationfiltered
  2. customevaporated

出典と根拠

ORDレコード
ord-0972fe45d0d440349bc00b18fda8efff
出典データセット
uspto-grants-2012_07
特許番号
US08222245B2

反応ノート

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